Post-doctoral position at UCL to work on the Brain in dystrophinopathies (BIND) project.
The job reference number is Ref:1873185.
We are looking for a highly motivated applicant with a PhD degree in neuroscience or a relevant subject. A strong background in protein analyses applied to the mammalian nervous system and experience with mouse work are highly desirable. The ideal candidate should have experience in protein purification, immunoblotting, sub-cellular fractionation, dissection of brain areas, and/or immuno-histochemistry on brain sections. Prior experience with proteomics and software for the analysis of protein/gene networks is desirable.
This post would last until 31 December 2023 in the first instance.
The project involves the characterization of the interactome of three dystrophin isoforms in the mouse brain using a functional proteomic approach in vivo. The candidate will characterize the composition of these brain dystrophin-associated protein complexes, localize the newly discovered dystrophin associated proteins in the mouse and human brain, determine how they are affected by genetic mutations affecting different dystrophin isoforms, and assess the impact of an exon-skipping treatment approach in a mouse model of DMD in normalizing their expression/localization.
If you have any queries regarding the application process, please contact Madhur Sharma on firstname.lastname@example.org quoting job reference 1873185.